We propose an l1penalized maximum likelihood estimator in an appropriate parameterization. Regularized maximumlikelihood estimation of mixtureof. We study confidence regions and approximate chisquared tests for variable groups in highdimensional linear regression. L1penalization for mixture regression models mafiadoc. Mixtures of linear regression models were introduced by quandt and ramsey 4 as a very general form of switching regression. Fitting finite mixtures of linear regression models with. L1 penalization for mixture regression models article pdf available in test 192.
High dimensional thresholded regression and shrinkage effect. Regularized maximumlikelihood estimation of mixtureofexperts for regression and clustering faicel chamroukhi and bao tuyen huynh abstractmixture of experts moe models are successful neuralnetwork architectures for modeling heterogeneous data in many machine learning problems including regression, clustering and classi. Journal of the royal statistical society series b 76, 141167. In this work, we introduce a novel regularized estimation scheme for learning nonparametric finite mixture of gaussian graphical models, which extends the methodology and applicability of gaussian graphical models and mixture models. Asymptotic properties for combined l1 and concave regularization. A new method for robust mixture regression information. Sorry, we are unable to provide the full text but you may find it at the following locations. The supported models at this moment are linear regression, logistic regression, poisson regression and the cox proportional hazards model, but others are likely to be included in the future. Several datasets which have been previously used in the literature to demonstrate the use of. We propose an 1penalized estimation procedure for highdimensional linear mixedeffects models. Like any regression model, the fmr model is used to study the relationship between response variables and a set of covariates. Variable selection for semiparametric regression models. Spike and slab models were extended to the class of rescaled spike and slab models ishwaran and rao, 2005.
Jun 30, 2010 this comment refers to the invited paper available at. Jun 30, 2010 we consider a finite mixture of regressions fmr model for highdimensional inhomogeneous data where the number of covariates may be much larger than sample size. In mixture models, it will be crucial to have a good estimator of. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Like any regression model, the fmr models are used to study the relationship between response variables and a set of covariates.
Fmr models combine the characteristics of regression models with those of. Regression mixture models are widely studied in statistics, machine learning and data analysis. Recently, the research about the mixture regression model. Finite mixtures of generalized linear regression models. Heuristically, large is interpreted as complex model. In section 3, we present our mixture of the local linear and quadratic approximationalgorithm for scad penalty and study its various.
Penalization for mixture regression models by nicolas st. This should lead to multivariate shrinkage of the vector. This kind of estimation belongs to a class of problems where optimization and theory for non. Spades and mixture models 3 is equivalent to soft thresholding 18, 30. This process is experimental and the keywords may be updated as the learning algorithm improves. A mixture of local and quadratic approximation variable. When the size of the group is small, lowdimensional projection estimators for individual coefficients can be directly used to construct efficient confidence regions and pvalues for the group. Instead of a discretecontinuous mixture, ishwaran and rao 2003, 2005 introduce gaussian. The true model is a mixture model of the form 1 for some integer k 0 of component models 1 models with those of. Robust mixture regression modeling based on scale mixtures of skewnormal distributions. We consider a finite mixture of regressions fmr model for highdimensional inhomogeneous data where the number of covariates may be. Then the mixture regression model attracted a lot of interest from statisticians. This kind of estimation belongs to a class of problems where optimization and theory for nonconvex functions is needed. It is wellknown that the least squares estimator is very sensitive to the outliers in the dataset.
Pdf on aug 1, 2010, anestis antoniadis and others published comments on. These problems require you to perform statistical model selection to. Scaled sparse linear regression jointly estimates the regression coefficients and noise level in a linear model. Existing methods, such as the akaike information criterion and the bayes information criterion, are computationally expensive as the number. In section 2, we present the local linear and quadratic approximation algorithms for scad penalty. At the same time, the conditional distribution of the response variable y given the covariates is a. Extending the akaike information criterion to mixture regression models prasad a.
Specifically, a finite mixture ofregressions fmr is used for modeling a continuous response as a function of covariates. On the one hand, penalization has been considered for regularizing regression models with a large number of covariates, where penalization introduces shrinkage of estimated coefficients towards zero e. Variable selection in finite mixture of regression models. The present study advances from published studies by considering semiparametric regression models. However, relatively few articles examining highdimensional regression problems involving a nonconvex loss function can be citedfor example, khalili and chen 2007 khalili, a. L1penalization for mixture regression models article pdf available in test 192. A mixture of local and quadratic approximation variable selection algorithm in. Prediction with a flexible finite mixtureofregressions. The weighted lasso is also used in the paper to attenuate the bias. In such problems, when there are many candidate predictors, it is not only of interest to identify the predictors that are associated with the outcome, but also to distinguish the true sources of heterogeneity, i.
Unsupervised learning of regression mixture models with. In the applications of finite mixture of regression fmr models, often many covariates are used, and their contributions to the response variable vary from one component to another of the mixture model. Researchers often have to deal with heterogeneous population with mixed regression relationships, increasingly so in the era of data explosion. Model uncertainty, penalization, and parsimony frank e harrell jr.
Penalized regression methods for linear models in sasstat funda gunes, sas institute inc. The fmr models combine the characteristics of the regression models with those of the. The lasso and elastic net algorithm that it implements is described in goeman 2010. Recently, the research about the mixture regression model is becoming more and more detailed.
Em and regression mixture modeling john myles white. By specifying random effects explicitly in the linear predictor of the mixture probability and the mixture components, parameter estimation is achieved by maximising the corresponding best linear unbiased prediction type loglikelihood. Estimation for highdimensional linear mixedeffects. Adaptive sparse group variable selection for a robust mixture. Specifically, a finite mixtureofregressions fmr is used for modeling a continuous response as a function of covariates. Existing methods, such as the akaike information criterion and the bayes information criterion, are computationally expensive. Inferring epigenetic and transcriptional regulation during. Robust variable selection for mixture linear regression models. We consider a finite mixture of regressions fmr model for highdimensional inhomogeneous data where the number of covariates may be much larger than sample size. Adaptive sparse group variable selection for a robust. This kind of estimation belongs to a class of problems where optimization and theory for nonconvex. Applications of finite mixtures of regression models. Abstract regression problems with many potential candidate predictor variables occur in a wide variety of scienti. The idea of achieving selection consistency via iterated penalization shares a similar spirit with that in meinshausen 2007, meinshausen and buhlmann 2006 and others.
We have recently shown that combining more than one regression model in a mixture, where each of the regression models explains the expression of a particular group of genes, improves the expression prediction and identification of important regulatory players costa et al. Penalized regression methods for linear models in sasstat. Abstract we consider a finite mixture of regressions fmr model for. Robust mixture regression modeling based on scale mixtures. The scad and also mcp penalty is nonconvex,and consequently it is hard to com. Home 2010 october 19 em and regression mixture modeling. Nonparametric finite mixture of gaussian graphical models. The models are useful whenever there is a grouping structure among high. A twocomponent mixture regression model that allows simultaneously for heterogeneity and dependency among observations is proposed. The generalization of 1penalized linear regression to the \mixtureofgaussianregressions model. These keywords were added by machine and not by the authors. Recently, 1 penalized methods have been extended to nonparametric regression with general xed.
Scad does not stop there, but continues to ameliorate the bias issue of lasso. Finite mixture regression models have been widely used for. Model selection consistency of the lasso type linear regression estimators is treated in many papers including 32, 47, 46, 48, 31. Unsupervised learning of regression mixture models with unknown number of components. We consider a finite mixture of regressions fmr model for high dimensional inhomogeneous data where the number of covariates. The conceptual differences between the approaches is again exploited in the empirical results. Mixture models represent a prime and important example where nonconvexity arises. Robust mixture regression modeling based on scale mixtures of. The generalization of 1penalized linear regression to the \ mixture ofgaussianregressions model. Request pdf on aug 1, 2010, nicolas stadler and others published rejoinder. In this section, we consider the mixture regression model where the random errors follow a scale mixtures of skewnormal distributions smsnmrm. We could end up with data like this if we had two classes of data points that each separately obey a standard linear regression model, but the models have different slopes for points from each of the two classes of data.
Extending the akaike information criterion to mixture. Bayesian regularisation in structured additive regression. Composite quantile regression and the oracle model selection theory1 by hui zou and ming yuan university of minnesota and georgia institute of technology coef. Within the family of mixture models, mixtures of linear regressions have also been studied extensively, especially when no information about membership of the points assigned to each line was available. Finite mixture regression model with random effects. Rescaling was shown to induce a nonvanishing penalization effect, and when used in tan. Composite quantile regression and the oracle model. Fitting regression mixtures is challenging and is usually performed by maximum likelihood by using the expectation. Pdf on aug 1, 2010, tingni sun and others published comments on. Request pdf on aug 1, 2010, eustasio del barrio and others published comments on. Scaled sparse linear regression biometrika oxford academic. Pdf pursuing sources of heterogeneity in modeling clustered.